Rapid Typhoid Detection.

IDL Biotech’s TUBEX® TF is a rapid and sensitive in vitro diagnostic test for the detection of acute typhoid fever, a disease caused by Salmonella typhi. 


TUBEX® TF can easily be performed in any laboratory or field setting, and with a result within 10 minutes. A positive TUBEX® TF result, together with typical clinical symptoms, is a strong indication of acute typhoid fever.

The test is a semiquantitative assay based on IMBI® technology (Inhibition Magnetic Binding Immunoassay), a simple assay technology based on visual interpretation.

A complement product to TUBEX® TF is TUBEX® TF Wash which is recommended to be used for the analysis of colored serum samples.

IDL Biotech is the legal manufacturer of TUBEX® TF and TUBEX® TF Wash.


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TUBEX® TF is characterized by high sensitivity and specificity. TUBEX® TF can be performed in any laboratory environment and the result is ready within 10 minutes.

Clinical evaluation

In a comparative study in the Philippines, Kawano and co-workers evaluated four antibody detection tests for typhoid fever. The sensitivity of TUBEX® TF was 95% at a specificity of 80%. In this study TUBEX® TF performed best among other analysed tests. TUBEX® TF has been clinically evaluated on more than 5000 patients in different endemic settings, showing consistent performance across multiple continents.  

References for TUBEX TF

Tarupiwa, A., Tapera, S., Mtapuri-Zinyowera, S., Gumbo, P., Ruhanya, V., Gudza-Mugabe, M., Majuru, N.M., Chinombe, N.: Evaluation of TUBEX TF and onsite Typhoid IgG/IgM Combo Rapid tests to detect Salmonella enterica serovar typhi infection during a typhoid outbreak in Harare, Zimbabwe. BMC Research Notes 2015;8.

Lelei, Walter, Andrew K. Nyerere, Robert S. Onsare and Samuel M Kariuki. “Performance of TUBEX® TF IgM Antibody Test Against Culture to Detect Typhoid Fever Among Hospitalized Patients in Nairobi County.” Journal of Biology, Agriculture and Healthcare (2019): n. pag.

Kawano RL, Leano SA, Agdamag D.M.: Comparison of serological test kits for diagnosis of typhoid fever in the Philippines. J Clin Microbiol 2007; 45: 246-247.

Rahman, M., Siddique, A.K., Tam, F.C.-H., Sharmin, S., Rashid, H., Iqbal, A., Ahmed, S., Nair, G.B., Chaignat, C.-L., Lim, P.-L.: Rapid detection of early typhoid fever in endemic community children by the TUBEX® O9-antibody test. Diagn Microbiol Infect Dis 2007; 58: 275-281.

Olsen, S.J., Pruckler, J., Bibb, W., Nguyen, T.M., Tran, M.T., Nguyen, T.M., Sivapalasingam, S., Gupta, A., Phan, T.P., Nguyen, T.C., Nguyen, V.C., Phung, D.C., Mintz, E.D.: Evaluation of rapid diagnostic tests for typhoid fever. J Clin Microbiol 2004; 42: 1885-1889.

Bundalian, R., Jr, Valenzuela, M., & Tiongco, R. E. (2019). Achieving accurate laboratory diagnosis of typhoid fever: a review and meta-analysis of TUBEX® TF clinical performance. Pathogens and global health113(7), 297–308.

Khanna, A., Khanna, M., Karamjit S.G. : Comparative evaluation of TUBEX TF for typhoid fever in endemic area. J of Clin. And Diagn Res. 2015 Nov, Vol-9(11): DC14-C`DC17.

Tam FCH., Leung DTM., Ma CH., Lim P-L.: Modification of the Tubex typhoid test to detect antibodies directly from haemolytic serum and whole blood. J Medical Microbiol 2008; 57: 1349-1353.

Lim, P-L., Tam, F., Cheong, Y-M., Jegathesan, M.: One-step 2-minute test to detect typhoid-specific antibodies based on particle separation in tubes. J Clin Microbiol 1998; 36: 2271-2278.

WHO. Background document: The diagnosis, treatment and prevention of typhoid fever. 2003; 11-16. WHO/V&B/03.07.


An effective typhoid test

Typhoid fever is water and food-borne infectious disease caused by the bacterium, Salmonella enterica. IDL Biotechs product TUBEX® TF, is a rapid and sensitive in vitro diagnostic test for the detection of acute typhoid fever.


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