Thymidine Kinase 1 (TK1) is an enzyme which is up-regulated in proliferating cells and peaks during of the S-phase of the cell cycle. The enzyme concentration is very low in resting cells.
Thymidine Kinase 1 has become increasingly interesting in cancer research, drug development and clinical oncology as it has been found that elevated levels of TK1 in blood is associated with the presence of malignancies.
A malignant tumor has high cell division, and TK1 leaks out into the blood as a consequence of cell disruption spontaneously or triggered by therapy. A sensitive routine test for measuring TK1 protein has therefore a great value in patient monitoring, clinical research, and in drug discovery and development.
Thymidine Kinase 1 is a valuable biomarker in subjects with many forms of cancer, including leukemia, lymphoma, breast, prostate, lung, sarcoma and colon cancer patients.